Antimicrobial abietane-type diterpenoids from Torreya grandis

作者：Jiao‐Jiao Cui, Weijia Li, Cheng-Lei Wang, Yi-Qi Huang, Wei Lin, Bin Zhou, Jian‐Min Yue · 发表于：Phytochemistry · 年份：2022 · DOI：10.1016/j.phytochem.2022.113278 · 被引用次数：26 · 研究领域：Biological Activity of Diterpenoids and Biflavonoids、Natural product bioactivities and synthesis、Plant biochemistry and biosynthesis

Twelve undescribed abietane-type diterpenoids, along with ten known analogues were isolated from the twigs and leaves of Torreya grandis var. merrillii Hu. Their structures were characterized by spectroscopic data analyses, single-crystal X-ray diffraction, and ECD spectra. Torgranols A-C possess three different architectures shaped via a common 6,7-seco-procedure and subsequent ring formations. In particular, torgranol A represents the first example of a 6,7-seco-abietane diterpenoid featuring a unique oxygen bridge between C-3 and C-6. The biosynthetic pathways for torgranols A-C were proposed. Some compounds displayed antimicrobial activities against Mycobacterium tuberculosis and/or Staphylococcus aureus.