Editorial: Epigenetic Variation Influences on Livestock Production and Disease Traits

作者：Eveline M. Ibeagha‐Awemu, Hélène Kiefer, Stephanie McKay, George E. Liu · 发表于：Frontiers in Genetics · 年份：2022 · DOI：10.3389/fgene.2022.942747 · 被引用次数：10 · 研究领域：Genetic Mapping and Diversity in Plants and Animals、Genetic and phenotypic traits in livestock、Cancer-related molecular mechanisms research

Epigenetic Variation Influences on Livestock Production and Disease TraitsThe epigenome source of variation modulates gene expression without involving changes to the DNA sequence and is an underutilized source of information that may contribute to improved disease management, reproduction, productivity, and environmental adaptation of livestock.The epigenome which comprises DNA methylation, histone tail modifications, chromatin remodeling, and non-coding RNA species that can transmit epigenetic information (e.g.microRNAs and long non-coding RNAs, etc.) responds to environmental factors (nutrition, pathogens, and climate, etc.) to influence the expression of genes and the emergence of specific phenotypes.Increasing evidence indicates that phenotypic expression results from multi-level interactions between the genome, epigenome, environmental factors, and other non-genetic factors.Furthermore, numerous lines of evidence suggest the influence of epigenome variation on livestock production (e.g.milk production), disease traits, reproduction, and environmental adaptation.Given that livestock breeding depends heavily on the interaction between host genetics, environment (e.g.cold or warm climate, nutrition, pathogens, etc.), physiology (e.g.age) and management practices (e.g.type of feed material, form/ quantity of feed), many of which impact the epigenome, it is imperative that attention should be given to epigenome characterization and application in livestock breeding and disea...