Association of Sitting Time With Mortality and Cardiovascular Events in High-Income, Middle-Income, and Low-Income Countries

作者：Sidong Li, Scott A. Lear, Sumathy Rangarajan, Bo Hu, Lu Yin, Shrikant I. Bangdiwala, Khalid F. AlHabib, Annika Rosengren, Rajeev Gupta, Prem Mony, Andreas Wielgosz, Omar Rahman, M. Y. Mazapuspavina, Álvaro Avezum, Aytekin Oğuz, Karen Yeates, Fernando Laņas, Antonio Dans, Marc Evans M. Abat, Afzalhussein Yusufali, Rafael Díaz, Patricio López‐Jaramillo, Lloyd Leach, P. V. M. Lakshmi, Alicja Basiak-Rasała, Romaina Iqbal, Roya Kelishadi, Jephat Chifamba, Rasha Khatib, Wei Li, Salim Yusuf · 发表于：JAMA Cardiology · 年份：2022 · DOI：10.1001/jamacardio.2022.1581 · 被引用次数：134 · 研究领域：Physical Activity and Health、Obesity, Physical Activity, Diet、Cardiac Health and Mental Health

Importance: High amounts of sitting time are associated with increased risks of cardiovascular disease (CVD) and mortality in high-income countries, but it is unknown whether risks also increase in low- and middle-income countries. Objective: To investigate the association of sitting time with mortality and major CVD in countries at different economic levels using data from the Prospective Urban Rural Epidemiology study. Design, Setting, and Participants: This population-based cohort study included participants aged 35 to 70 years recruited from January 1, 2003, and followed up until August 31, 2021, in 21 high-income, middle-income, and low-income countries with a median follow-up of 11.1 years. Exposures: Daily sitting time measured using the International Physical Activity Questionnaire. Main Outcomes and Measures: The composite of all-cause mortality and major CVD (defined as cardiovascular death, myocardial infarction, stroke, or heart failure). Results: Of 105 677 participants, 61 925 (58.6%) were women, and the mean (SD) age was 50.4 (9.6) years. During a median follow-up of 11.1 (IQR, 8.6-12.2) years, 6233 deaths and 5696 major cardiovascular events (2349 myocardial infarctions, 2966 strokes, 671 heart failure, and 1792 cardiovascular deaths) were documented. Compared with the reference group (<4 hours per day of sitting), higher sitting time (≥8 hours per day) was associated with an increased risk of the composite outcome (hazard ratio [HR], 1.19; 95% CI, 1.11-1.28; ...