First Report of the Colistin Resistance Gene mcr-10.1 Carried by Inc pA1763-KPC Plasmid pSL12517-mcr10.1 in Enterobacter cloacae in Sierra Leone

作者：Jiayao Guan, Letian Li, Lin Zheng, Gejin Lu, Ying Wang, Sulaiman Lakoh, Stephen Sevalie, Bowen Jiang, Xue Ji, Yang Sun, Jun Liu, Lingwei Zhu, Xuejun Guo · 发表于：Microbiology Spectrum · 年份：2022 · DOI：10.1128/spectrum.01127-22 · 被引用次数：22 · 研究领域：Antibiotic Resistance in Bacteria、Pharmaceutical and Antibiotic Environmental Impacts、Genomics and Phylogenetic Studies

Colistin is used as one of the last available choices of antibiotics for patients infected by carbapenem-resistant bacterial strains, but the unrestricted use of colistin aggravated the acquisition and dissemination of mobile colistin resistance ( mcr ) genes. So far, 10 mcr genes have been reported in four continents around the world.