CARIBOU‐1: A pilot controlled trial of an Integrated Care Pathway for the treatment of depression in adolescents

作者：Darren Courtney, Amy Cheung, Joanna Henderson, Kathryn Bennett, Wei Wang, Sheng Chen, Marco Battaglia, John S. Strauss, Rachel Mitchell, Karen Wang, Jacqueline Relihan, Matthew Prebeg, Karleigh Darnay, Peter Szatmari · 发表于：JCPP Advances · 年份：2022 · DOI：10.1002/jcv2.12083 · 被引用次数：21 · 研究领域：Child and Adolescent Psychosocial and Emotional Development、Health Policy Implementation Science、Childhood Cancer Survivors' Quality of Life

Abstract Background To co‐ordinate a multidisciplinary team in the delivery of guideline recommendations using a measurement‐based care framework, our group previously developed a care pathway for the treatment of depression in adolescents. Core components of the pathway were: assessment, education, cognitive‐behavioural therapy, a caregiver intervention group, a medication algorithm, and monthly measurement‐based care “team reviews” with the adolescent present. The aim of this study was to test the feasibility of conducting a controlled clinical trial of the pathway. Method We conducted a 20‐week pilot controlled clinical trial of the care pathway relative to treatment as usual. Participants were adolescents (age 14–18) with a primary diagnosis of Major Depressive Disorder recruited from one of two outpatient psychiatric clinics at academic hospitals. Site of presentation was the method of allocation. Thirty‐five youth were allocated to the pathway and 31 were allocated to treatment as usual. As this is a pilot study, trial feasibility outcomes were of primary interest, including clinician fidelity to the care pathway. Results Our target sample size was recruited over a 15‐month time interval. Clinician fidelity and adolescent engagement in the care pathway components on a priori checklists were high (95% and 80%, respectively). We collected baseline and 20‐week endpoint data for our primary outcome of the Children's Depression Rating Scale – Revised (CDRS‐R) for 83% of the ...