White Paper on European Patient Needs and Suggestions on Chronic Type 2 Inflammation of Airways and Skin by EUFOREA

作者：Louise De Prins, Ulrike Raap, Tara Mueller, Peter Schmid‐Grendelmeier, Christiane H. Haase, Vibeke Backer, Wytske J. Fokkens, Linda B. L. Benoist, Emmanuel Prokopakis, Maria Doulaptsi, Claire Hopkins, N. Claeys, Thijs Teeling, Lindsay Cypers, Leen Cools, Leif Bjermer, Zuzana Diamant, Ulrich Wahn, Glenis Scadding, Claus Bachert, Peter Walther, Sunni R. Patel, Elizabeth Van Staeyen, Peter W. Hellings · 发表于：Frontiers in Allergy · 年份：2022 · DOI：10.3389/falgy.2022.889221 · 被引用次数：41 · 研究领域：Sinusitis and nasal conditions、Allergic Rhinitis and Sensitization、Dermatology and Skin Diseases

Background: Type 2 inflammation underlies the chronicity of disease in subgroups of patients with asthma, chronic rhinosinusitis with nasal polyps (CRSwNP) and atopic dermatitis (AD), that often co-exist. Although several studies have investigated the unmet needs of asthma, AD and CRSwNP as such, little is known about the similarities and differences in experiences and perspectives of the current management of patients with comorbid Type 2 inflammatory diseases. Aims: To improve insight into the common and organ-specific needs of patients with Type 2 inflammation and comorbidities, allowing the formulation of recommendations to better address these needs in the future. Methodology: This qualitative study was conducted between July 2021 and December 2021 using semi-structured face-to-face or telephone interviews with patients suffering from year-long severe chronic Type 2 inflammation and at least one co-morbid inflammatory condition. Seven participating academic centers in Europe interviewed asthma (Copenhagen and Leuven), CRSwNP (London, Amsterdam and Crete) and/or AD (Oldenburg and Zurich) patients on patient characteristics, disease severity, shortcomings of current care pathways and suggestions for improvement of care. Transcripts were analyzed using an inductive thematic analysis approach. Results: Eighty-one patients with severe Type 2 inflammation and comorbidities were interviewed. Similar needs were recognized by patients with Type 2 inflammation, with both a lack of...