Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs

作者：Robert S. Jones, Christian Leung, Jae H. Chang, Suzanne J. Brown, Ning Liu, Zhengyin Yan, Jane R. Kenny, Fabio Broccatelli · 发表于：Drug Metabolism and Disposition · 年份：2022 · DOI：10.1124/dmd.121.000784 · 被引用次数：37 · 研究领域：Computational Drug Discovery Methods、Pharmacogenetics and Drug Metabolism、Analytical Chemistry and Chromatography