Thrombophilia testing: A British Society for Haematology guideline

作者：Deepa J. Arachchillage, Lucy Mackillop, Arvind Chandratheva, Jayashree Motawani, Peter MacCallum, Michael Laffan · 发表于：British Journal of Haematology · 年份：2022 · DOI：10.1111/bjh.18239 · 被引用次数：144 · 研究领域：Blood Coagulation and Thrombosis Mechanisms、Venous Thromboembolism Diagnosis and Management、Hemophilia Treatment and Research

This guideline was compiled according to the BSH process at [https://b-s-h.org.uk/media/16732/bsh-guidance-development-process-dec-5-18.pdf]. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) nomenclature was used to evaluate levels of evidence and to assess the strength of recommendations. The GRADE criteria can be found at http://www.gradeworkinggroup.org. A literature search was carried out using the terms given in Appendix S1 until April 2021. Review of the manuscript was performed by the BSH Haemostasis and Thrombosis Task Force, the BSH Guidelines Committee and the sounding board of BSH. It was also placed on the members section of the BSH website for comment. It has also been reviewed by Royal College of Obstetricians and Gynaecologists, Royal College of Paediatrics and Child Health, Royal College of Physicians and Thrombosis UK, a patient-centred charity dedicated to promoting awareness, research and care of thrombosis; these organisations do not necessarily approve or endorse the contents. This guideline updates and widens the scope of the previous British Society for Haematology (BSH) Clinical guidelines for testing for heritable thrombophilia1 to include both heritable and acquired thrombophilia. The term thrombophilia is generally used to describe hereditary and/or acquired conditions associated with an increased predisposition to thrombosis. Heritable thrombophilia refers to genetic disorders of specific haemostatic proteins. These gui...