Diagnosis of Ureaplasma parvum meningitis by mNGS in an extremely low birth weight infant with multi-system lesions

作者：Jing Duan, Chuncheng Zhang, Jun Wang, Juanjuan Fu, Pingping Song, Feng Pang, Qigang Zhao, Zhiqing You · 发表于：Indian Journal of Medical Microbiology · 年份：2022 · DOI：10.1016/j.ijmmb.2022.05.001 · 被引用次数：4 · 研究领域：Cytomegalovirus and herpesvirus research、Reproductive tract infections research、Microbial infections and disease research

Ureaplasma parvum encephalitis is a rare disease with high mortality in the neonates. While the manifestations are atypical and identification of U. parvum is difficult, diagnosis would always be delayed. Metagenomic next-generation sequencing (mNGS) is a pre-hypothesis free technique which could theoretically detect all the microbes in a sample. Herein we report a case of U. parvum meningitis identified by mNGS in an extremely low birth weight neonate complicated with multi-system lesions. The patient was treated with erythromycin and ciprofloxacin, symptoms were relieved in the following days and the patient was transferred to treat complications after three weeks' therapy.