A Survey of Helicobacter pylori Antibiotic-Resistant Genotypes and Strain Lineages by Whole-Genome Sequencing in China

作者：Yan Zhou, Zishao Zhong, Shengjuan Hu, Jing Wang, Yanhong Deng, Ximei Li, Xianmei Chen, Xue Li, Yuanyuan Tang, Xiaofei Li, Hao Qian, Jun Liu, Tian Sang, Bo Yang, Feihu Bai · 发表于：Antimicrobial Agents and Chemotherapy · 年份：2022 · DOI：10.1128/aac.02188-21 · 被引用次数：26 · 研究领域：Helicobacter pylori-related gastroenterology studies、Veterinary medicine and infectious diseases、Mycobacterium research and diagnosis

Antibiotic resistance is the most important factor leading to failed Helicobacter pylori eradication therapy, and personalized treatment based on antibiotic susceptibility is becoming increasingly important. To strengthen the understanding of antibiotic genotypic resistance of H. pylori and identify new antibiotic resistance loci, in this study, we identified phenotypic resistance information for 60 clinical isolates and compared the concordance of phenotypic and genotypic resistance using whole-genome sequencing (WGS).