Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)−H bonds

作者：Shaolong Qi, Yupeng Liu, Yi Li, Yu‐Xin Luan, Mengchun Ye · 发表于：Nature Communications · 年份：2022 · DOI：10.1038/s41467-022-30367-8 · 被引用次数：31 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions、Synthesis and Catalytic Reactions

Abstract Hydroarylation of alkynes with unactivated C(sp 2 )−H bonds via chelated C−H metalation mainly occurs at γ -position to the coordinating atom of directing groups via stable 5-membered metallacycles, while β -C(sp 2 )−H bond-involved hydroarylation has been a formidable challenge. Herein, we used a phosphine oxide-ligated Ni−Al bimetallic catalyst to enable β -C−H bond-involved hydroarylations of alkynes via a rare 7-membered nickelacycle.