A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy

作者：Yeon Sik Choi, Hyoyoung Jeong, Rose T. Yin, Raudel Avila, Anna Pfenniger, Jae‐Young Yoo, Jong Yoon Lee, Andreas Tzavelis, Young Joong Lee, Sheena W. Chen, Helen S. Knight, Seungyeob Kim, Hak‐Young Ahn, Grace Wickerson, Abraham Vázquez‐Guardado, Elizabeth Higbee‐Dempsey, B Russo, Michael A. Napolitano, Timothy J. Holleran, Leen Abdul Razzak, Alana N. Miniovich, Geumbee Lee, Beth Geist, Brandon Kim, Shuling Han, Jaclyn A. Brennan, Kedar Aras, Sung Soo Kwak, Joohee Kim, Emily A. Waters, Xiangxing Yang, Amy Burrell, Keum San Chun, Claire Liu, Changsheng Wu, Alina Y. Rwei, Alisha N. Spann, Anthony Banks, David A. Johnson, Zheng Jenny Zhang, Chad R. Haney, Sung Hun Jin, Alan V. Sahakian, Yonggang Huang, Gregory D. Trachiotis, Bradley P. Knight, Rishi Arora, Igor R. Efimov, John A. Rogers · 发表于：Science · 年份：2022 · DOI：10.1126/science.abm1703 · 被引用次数：264 · 研究领域：Wireless Body Area Networks、Advanced Sensor and Energy Harvesting Materials、Wireless Power Transfer Systems

Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.