An Altered Microbiota in the Lower and Upper Female Reproductive Tract of Women with Recurrent Spontaneous Abortion

作者：Fen-Ting Liu, Shuo Yang, Zi Feng Yang, Ping Zhou, Tianliu Peng, Jingwen Yin, Zhenhong Ye, Hongying Shan, Yang Yu, Rong Li · 发表于：Microbiology Spectrum · 年份：2022 · DOI：10.1128/spectrum.00462-22 · 被引用次数：69 · 研究领域：Reproductive tract infections research、Reproductive System and Pregnancy、Reproductive Health and Contraception

As an obstacle to pregnancy, recurrent spontaneous abortion (RSA) can be caused by a variety of factors, and a current understanding of the etiology of RSA is still lacking; half of cases have an unknown cause. A substantial fraction of patients show no improvement after treatment. Since the microbiota of the female reproductive tract has been proposed as an emerging factor in RSA patients, further investigation is needed to provide guidance for clinical therapy. In general, this is the first report describing the distinct alterations of the vaginal, cervical, and uterine microbiota in RSA, not just that in the vagina. Furthermore, another major strength of this study derived from the further in-depth investigation and analysis of the characteristics of the microbiota colonizing the upper female genital tract in RSA, which provided a more comprehensive view for investigating the uterine microbiota.