Histone Modifications and Non-Coding RNAs: Mutual Epigenetic Regulation and Role in Pathogenesis

作者：Irina Vladimirovna Bure, Marina V. Nemtsova, Ekaterina Kuznetsova · 发表于：International Journal of Molecular Sciences · 年份：2022 · DOI：10.3390/ijms23105801 · 被引用次数：252 · 研究领域：Cancer-related molecular mechanisms research、RNA modifications and cancer、Epigenetics and DNA Methylation

In the last few years, more and more scientists have suggested and confirmed that epigenetic regulators are tightly connected and form a comprehensive network of regulatory pathways and feedback loops. This is particularly interesting for a better understanding of processes that occur in the development and progression of various diseases. Appearing on the preclinical stages of diseases, epigenetic aberrations may be prominent biomarkers. Being dynamic and reversible, epigenetic modifications could become targets for a novel option for therapy. Therefore, in this review, we are focusing on histone modifications and ncRNAs, their mutual regulation, role in cellular processes and potential clinical application.