Discovery of brevijanazines from Aspergillus brevijanus reveals the molecular basis for p -nitrobenzoic acid in fungi

作者：Hang Li, Paul M. Mirzayans, Mark S. Butler, Alastair E. Lacey, Daniel Vuong, Rachel Chen, John A. Kalaitzis, Stephen A. Moggach, Ernest Lacey, Andrew M. Piggott, Yit‐Heng Chooi · 发表于：Chemical Communications · 年份：2022 · DOI：10.1039/d2cc01679f · 被引用次数：13 · 研究领域：Microbial Natural Products and Biosynthesis、Oxidative Organic Chemistry Reactions、Alkaloids: synthesis and pharmacology

The discovery of a novel family of p -nitrobenzoylated piperazines from Aspergillus brevijanus revealed that the biosynthesis of p -nitrobenzoic acid in fungi is catalysed by a PABA synthase, an aminodeoxychorismate synthase and a cytochrome P450.