Boronic Acid-Decorated Multivariate Photosensitive Metal–Organic Frameworks for Combating Multi-Drug-Resistant Bacteria

作者：Mian Chen, Jiangjiang Zhang, Jie Qi, Ruihua Dong, Hongmei Liu, Decheng Wu, Huawu Shao, Xingyu Jiang · 发表于：ACS Nano · 年份：2022 · DOI：10.1021/acsnano.1c11613 · 被引用次数：127 · 研究领域：Nanoplatforms for cancer theranostics、Metal-Organic Frameworks: Synthesis and Applications、Antimicrobial agents and applications

Metal-organic frameworks (MOFs) are promising photosensitized materials that have displayed great advantages in antibacterial application. However, their bactericidal activity is still limited by the ultrashort diffusion distance of biocidal reactive oxygen species (ROS). Herein, we integrate the bacterial-binding boronic acid ligand and photosensitized porphyrin into one single MOF, synergistically boosting antibiotic capability. The introduction of the boronic acid group with a closed physical gap makes multivariate MOFs more powerful for eradicating multi-drug-resistant (MDR) bacteria. The MOFs that are decorated with boronic acid possess antibacterial efficiencies (10-20 times) higher than those without the targeting ligand. Moreover, the MOFs exhibit excellent biocompatibility. They significantly decrease the inflammatory responses and accelerate the healing of chronic wounds infected with MDR bacteria (nearly 2 times faster). This work provides a strategy to develop multivariate MOFs that target bacteria, which will further inspire specific bacterial-binding therapy in the future.