Exposure to per- and polyfluoroalkyl substances and body composition in US adolescents aged 12-18 years: an analysis of data from the National Health and Nutrition Examination Surveys 2011-2018

作者：Li‐Zi Lin, Li Cai, Zhao-Yan Liu, Jian Gao, Yang Zhou, Xiaoyun Zeng, Yanqiu Ou, Guoping Dong, Guoping Dong, Pengxin Dong, Qi-Zhen Wu, Chu Chu, Lu-Yin Wu, Li-Xia Liang, Shuang-Jian Qin, Xiao‐Wen Zeng, Xiaomiao Zhao, Guang‐Hui Dong, Guang‐Hui Dong · 发表于：Hygiene and Environmental Health Advances · 年份：2022 · DOI：10.1016/j.heha.2022.100009 · 被引用次数：14 · 研究领域：Per- and polyfluoroalkyl substances research、Air Quality and Health Impacts、Atmospheric chemistry and aerosols

The associations between per- and polyfluoroalkyl substances (PFAS) and obesity in adolescent remained unclear when considering imaging based methods such as dual-energy X-ray absorptiometry (DXA) scanning. The 2011-2018 National Health and Nutrition Examination Survey (NHANES) was used in this study. There were four highly detected PFAS including perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA). We calculated total mass, fat mass and fat-free mass (i.e., lean mass including bone mineral content) indexes (mass/height2) of total body and three regions [head, trunk and subtotal (i.e., total minus head)]. We assessed the associations using weighted multivariable linear regression and weighted quantile sum (WQS) regression. A total of 1067 participants aged 12-18 years were included in this study. When adjusting for potential covariates, PFHxS exposure was negatively associated with total fat mass index while positively associated with total fat-free mass index [β=-0.16, 95% confidence interval (CI): -0.27 to -0.04; β=0.16, 95%CI: 0.05 to 0.28]. When entering the PFAS mixture in the WQS model, we found similar associations of WQS index with total fat or fat-free mass index (β=-0.04, 95%CI: -0.08 to -0.00; β=0.04, 95%CI: 0.00 to 0.08). Within the PFAS mixture, PFOA exposure made major contributions to the overall effect (56.6% and 44.1% for total fat and fat-free mass index). We did not fi...