Long non-coding RNA muskelin 1 antisense RNA as a potential therapeutic target in hepatocellular carcinoma treatment

作者：Xijun Chen, Qingsong Ye, Zhigao Chen, Lin Qian, Wen Chen, Chengrong Xie, Xiaomin Wang · 发表于：Bioengineered · 年份：2022 · DOI：10.1080/21655979.2022.2074703 · 被引用次数：25 · 研究领域：Cancer-related molecular mechanisms research、Molecular Biology Techniques and Applications、RNA modifications and cancer

Long non-coding RNAs are essential to hepatocellular carcinoma (HCC) development, progression, and incidence of drug resistance. However, the biological significance of long non-coding RNA muskelin 1 antisense RNA (MKLN1-AS) remains poorly characterized. In this study, we observed noticeable increased levels of MKLN1-AS in HCC tissues. This upregulation of MKLN1-AS was clinically associated with vascular invasion and decreased disease-free survival and overall survival of patients with HCC. Functionally, MKLN1-AS-knockdown dramatically suppressed the metastasis and growth of HCC cells in vitro and in vivo. Additionally, the knockdown of MKLN1-AS augmented the pro-apoptosis effect of lenvatinib. Taken together, our findings indicate that MKLN1-AS may be exploited as a potential prognostic predictor and therapeutic target for HCC treatment.