Versatile polyphenolic platforms in regulating cell biology

作者：Huấn Cao, Lei Yang, Rong Tian, Haoxing Wu, Zhipeng Gu, Yiwen Helen Li · 发表于：Chemical Society Reviews · 年份：2022 · DOI：10.1039/d1cs01165k · 被引用次数：210 · 研究领域：3D Printing in Biomedical Research、Nanoparticle-Based Drug Delivery、Nanoplatforms for cancer theranostics

, antioxidant and photothermal behaviors). As such, a comprehensive understanding on the relationship between material properties and desired biomedical applications, as well as the underlying mechanism at the cellular and molecular level would provide material design principles and accelerate the lab-to-clinic translation of polyphenolic platforms. In this review, we firstly give a brief overview of cell hallmarks governed by surrounding cues, followed by the introduction of polyphenolic material engineering strategies. Subsequently, a detailed discussion on cell-polyphenols contact-dependent interfacial interaction and contact-independent interaction was also carefully provided. Lastly, their biomedical applications were elaborated. We believe that this review could provide guidances for the rational material design of multifunctional polyphenols and extend their application window.