Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis

作者：Yunjuan Nie, Shuohua Wu, Ying-Hua Xuan, Gen Yan · 发表于：Military Medical Research · 年份：2022 · DOI：10.1186/s40779-022-00382-3 · 被引用次数：84 · 研究领域：Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis、IL-33, ST2, and ILC Pathways、Asthma and respiratory diseases

Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease with no established treatment and is characterized by progressive scarring of the lung tissue and an irreversible decline in lung function. Chronic inflammation has been demonstrated to be the pathological basis of fibrosis. Emerging studies have revealed that most interleukin-17 (IL-17) isoforms are essential for the mediation of acute and chronic inflammation via innate and adaptive immunity. Overexpression or aberrant expression of IL-17 cytokines contributes to various pathological outcomes, including the initiation and exacerbation of IPF. Here, we aim to provide an overview of IL-17 family members in the pathogenesis of IPF.