Incidences of Infectious Events in a Renal Transplant Cohort of the German Center of Infectious Diseases (DZIF)

作者：Claudia Sommerer, Iris Schröter, Katrin Gruneberg, Daniela Schindler, Rouven Behnisch, Christian P. Morath, Lutz Renders, Uwe W. Heemann, Paul Schnitzler, Anette Melk, Andrea Della Penna, Silvio Nadalin, Klaus M. Heeg, Stefan C Meuer, Martin Zeier, Thomas Giese · 发表于：Open Forum Infectious Diseases · 年份：2022 · DOI：10.1093/ofid/ofac243 · 被引用次数：32 · 研究领域：Cytomegalovirus and herpesvirus research、Pneumocystis jirovecii pneumonia detection and treatment、Renal Transplantation Outcomes and Treatments

Abstract Background Infectious complications are a major cause of morbidity and mortality after kidney transplantation. Methods In this transplant cohort study at the German Center of Infectious Diseases (DZIF), we evaluated all infections occurring during the first year after renal transplantation. We assessed microbial etiology, incidence rates, and temporal occurrence of these infections. Results Of 804 renal transplant recipients (65.2% male, 51 ± 14 years), 439 (54.6%) had 972 infections within the first year after transplantation. Almost half of these infections (47.8%) occurred within the first 3 months. Bacteria were responsible for 66.4% (645/972) of all infections, followed by viral (28.9% [281/972]) and fungal (4.7% [46/972]) pathogens. The urinary tract was the most common site of infection (42.4%). Enterococcus was the most frequently isolated bacterium (20.9%), followed by E. coli (17.6%) and Klebsiella (12.5%). E. coli was the leading pathogen in recipients <50 years of age, whereas Enterococcus predominated in older recipients. Resistant bacteria were responsible for at least 1 infection in 9.5% (76/804) of all recipients. Viral infections occurred in 201 recipients (25.0%). Of these, herpes viruses predominated (140/281 [49.8%]), and cytomegalovirus had the highest incidence rate (12.3%). In the 46 fungal infections, Candida albicans (40.8%) was the most commonly isolated. Other fungal opportunistic pathogens, including Aspergillus fumigatus and Pneumocystis,...