The effect of perceived stress on cognition is mediated by personality and the underlying neural mechanism

作者：Ximei Zhu, Wei Yan, Xiao Lin, Jianyu Que, Yuetong Huang, Haohao Zheng, Lin Liu, Jiahui Deng, Lin Lü, Suhua Chang · 发表于：Translational Psychiatry · 年份：2022 · DOI：10.1038/s41398-022-01929-7 · 被引用次数：26 · 研究领域：Functional Brain Connectivity Studies、Stress Responses and Cortisol、Heart Rate Variability and Autonomic Control

Perceived stress impairs cognitive function across the adult lifespan, but the extent to which cognition decline is variable across individuals. Individual differences in the stress response are described as personality traits. Substantial individual differences in the magnitude of cognitive impairment that is induced by short-term perceived stress are poorly understood. The present study tested the hypothesis that the relationship between short-term perceived stress and different aspects of cognition is mediated by personality traits. The study included 1066 participants with behavior and neuroimaging data from the Human Connectome Project after excluding individuals with missing variables. In the result, the parallel multiple mediation model demonstrated that the influence of perceived stress on the total and crystalized cognition is mainly mediated by neuroticism (indirect effect = -0.04, p < 0.05) and conscientiousness (indirect effect = 0.05, p < 0.05) in adults. Cortical thickness value (n = 1066) of the right superior frontal gyrus (SFG) showed not only positive correlations with short-term perceived stress and neuroticism, but negative associations with cognition. The chain mediation model found that the right SFG and neuroticism play a small but significant chain mediating effect between stress and total cognition. The strength of the resting-state functional connectivity (n = 968) between the left orbitofrontal cortex versus the left superior medial frontal cortex w...