Evaluating vaccination strategies to control foot-and-mouth disease: a country comparison study

作者：Thomas G. Rawdon, M.G. Garner, R.L. Sanson, Mark A. Stevenson, Connor Cook, Colin Birch, Sharon Roche, Kelly Patyk, K Forde-Folle, Caroline Dubé, T. Smylie, ZD Yu · 发表于：Epidemiology and Infection · 年份：2018 · DOI：10.1017/s0950268818001243 · 被引用次数：28 · 研究领域：Animal Disease Management and Epidemiology、Vector-Borne Animal Diseases、Viral Infections and Immunology Research

Abstract Vaccination is increasingly being recognised as a potential tool to supplement ‘stamping out’ for controlling foot-and-mouth disease (FMD) outbreaks in non-endemic countries. Infectious disease simulation models provide the opportunity to determine how vaccination might be used in the face of an FMD outbreak. Previously, consistent relative benefits of specific vaccination strategies across different FMD simulation modelling platforms have been demonstrated, using a UK FMD outbreak scenario. We extended this work to assess the relative effectiveness of selected vaccination strategies in five countries: Australia, New Zealand, the USA, the UK and Canada. A comparable, but not identical, FMD outbreak scenario was developed for each country with initial seeding of Pan Asia type O FMD virus into an area with a relatively high density of livestock farms. A series of vaccination strategies (in addition to stamping out (SO)) were selected to evaluate key areas of interest from a disease response perspective, including timing of vaccination, species considerations (e.g. vaccination of only those farms with cattle), risk area vaccination and resources available for vaccination. The study found that vaccination used with SO was effective in reducing epidemic size and duration in a severe outbreak situation. Early vaccination and unconstrained resources for vaccination consistently outperformed other strategies. Vaccination of only those farms with cattle produced comparable re...