Prediction of risk factors of bronchial mucus plugs in children with Mycoplasma pneumoniae pneumonia

作者：Jiahui zhang, Ting Wang, Wei Ji, Yongdong Yan, Zhichao Sun, Jiahong Tan, Jinfeng Wu, Li Huang, Zhengrong Chen · 发表于：Research Square · 年份：2020 · DOI：10.21203/rs.3.rs-54708/v1 · 被引用次数：4 · 研究领域：Pneumonia and Respiratory Infections、Respiratory viral infections research、Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Abstract Background Recently, many cases of pneumonia with Mycoplasma pneumoniae ( M. pneumoniae ) infection have been shown to have varying degrees of intrabronchial mucus plug formation. The clinical, laboratory, radiological characteristics, and treatment of patients with Mycoplasma infection are analyzed in this study. The risk factors for M. pneumoniae pneumonia (MPP) mucus plug formation are explored, and a risk factor scoring system is established. Methods MPP patients treated with bronchoscopy were retrospectively enrolled in the study from February 2015 to December 2019. The children were divided into a mucus plug group and a control group according to the presence or absence of mucus plug formation. The clinical, laboratory, radiological characteristics, and treatment of the two groups of children were compared. The receiver operating characteristic (ROC) curve was drawn to evaluate the regression model and establish the MPP mucous plug risk factor scoring system. Results A univariate analysis showed that the children in the mucous group were older and had a longer fever duration, longer hospital stay, higher fever peak, more cases of wheezing symptoms and allergies, and azithromycin or corticosteroids were administered later. In addition, neutrophil, C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer (DD), sputum MP-DNA copy number, and total immunoglobulin A (IgA) levels were higher, while prealbumin (PA) levels were lower. The ROC curve analysis showe...