Interleukin-5, eosinophils, and disease

作者：CJ Sanderson · 发表于：Blood · 年份：1992 · DOI：10.1182/blood.v79.12.3101.bloodjournal79123101 · 被引用次数：788 · 研究领域：Eosinophilic Disorders and Syndromes、Insects and Parasite Interactions、Parasitic Infections and Diagnostics

OSINOPHIL production can be induced in vitro by E interleukin-3 (IL-3), granulocyte-macrophage colonystimulating factor (GM-CSF), and IL-5.Both IL-3 and GM-CSF have activities on other hemopoietic lineages, whereas IL-5 is specific for the eosinophil/basophil lineage.The activity of IL-5 on basophils has been reviewed recently' and will not be discussed here.There is now good evidence that IL-5 is the major, and possibly the only, cytokine involved in the production of specific eosinophilia.Classically eosinophilia is observed in a restricted number of diseases, most notably helminth infections and allergic diseases.However, although the increase in eosinophil numbers is less spectacular, there is increasing evidence for an involvement of eosinophils in a wider spectrum of diseases.A study of experimental infection of volunteers by the hookworm Necator americanus gave clear evidence for an increase in eosinophils with no significant increase in other blood leucocytes,2 and infection of mice with the cestode Mesocestoides Corti causes a massive increase in blood and peritoneal eosinophils with little effect on the number of ne~trophils.~This biologic specificity, the relatively restricted disease profile of eosinophilia, and the requirement for a functional T-lymphocyte ~y s t e m ~-~ suggested that the control of eosinophilia must be part of the immune response and based on a subset of T celk7Eosinophils are cytotoxic cells capable of killing helminths, parasitic protozoa, ch...