Design, Synthesis, and Antiviral Activity of α-Aminophosphonates Bearing a Benzothiophene Moiety

作者：Peiwei Zhang, Chenghao Tang, Zhiwei Chen, Bo Wang, Xiang Wang, Linhong Jin, Song Yang, Deyu Hu · 发表于：Phosphorus, sulfur, and silicon and the related elements · 年份：2013 · DOI：10.1080/10426507.2013.829837 · 被引用次数：12 · 研究领域：Organophosphorus compounds synthesis、Fungal Plant Pathogen Control、Ferrocene Chemistry and Applications

A series of α-aminophosphonates containing a benzothiophene moiety was designed and synthesized. All synthesized compounds were confirmed by 1H NMR, 13C NMR, 31P NMR, infrared spectroscopy, and elemental analysis. The half-leaf method was used to determine the in vivo efficacy of α-aminophosphonates bearing a benzothiophene moiety against the tobacco mosaic virus (TMV). Bioassay results showed that all compounds exhibited certain anti-TMV activity at 500 μg/mL concentration. Compound 2f exhibited a curative effect of up to 48.1% against TMV, which was almost similar to that obtained from the standard ningnanmycin (51.9%). [Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional text, figures, and tables.]