Antidepressants for the negative symptoms of schizophrenia

作者：Christine Rummel, Werner Kissling, Stefan Leucht · 发表于：Cochrane Database of Systematic Reviews · 年份：2006 · DOI：10.1002/14651858.cd005581 · 被引用次数：45 · 研究领域：Schizophrenia research and treatment、Electroconvulsive Therapy Studies、Treatment of Major Depression

Background Negative symptoms are common in people with schizophrenia and are often difficult to treat with antipsychotic drugs. Treatment often involves the use of various add‐on medications such as antidepressants. Objectives To review the effects of the combination of antipsychotic and antidepressant drug treatment for management of negative symptoms in schizophrenia and schizophrenia‐like psychoses. Search methods We searched the Cochrane Schizophrenia Group's register (January 2004). We also contacted authors of included studies in order to identify further trials. Selection criteria We included all randomised controlled trials comparing antipsychotic and antidepressant combinations with antipsychotics alone for the treatment of prominent negative symptoms in schizophrenia and/or schizophrenia‐like psychoses. Data collection and analysis Working independently, we selected and critically appraised studies, extracted data and analysed on an intention‐to‐treat basis. Where possible and appropriate we calculated the relative risk RR) and their 95% confidence intervals (CI), with the number needed to treat (NNT). Main results We included five studies (all short‐term, total N=190). We found no significant difference for 'leaving the study early for any reason' between the antipsychotic plus antidepressant combination and the control group (n=90, 3 RCTs, RR 3.0 CI 0.35 to 26.04). Leaving early due to adverse events (n=64, 2 RCTs, RR 5.0 CI 0.26 to 97.0) and leaving the study ear...