Gene Expression Profiles in Normal and Cancer Cells

作者：Lin Zhang, Wei Zhou, Victor E. Velculescu, Scott E. Kern, Ralph H. Hruban, Stanley R. Hamilton, Bert Vogelstein, Kenneth W. Kinzler · 发表于：Science · 年份：1997 · DOI：10.1126/science.276.5316.1268 · 被引用次数：1195 · 研究领域：Epigenetics and DNA Methylation、RNA modifications and cancer、Genetic factors in colorectal cancer

As a step toward understanding the complex differences between normal and cancer cells in humans, gene expression patterns were examined in gastrointestinal tumors. More than 300,000 transcripts derived from at least 45,000 different genes were analyzed. Although extensive similarity was noted between the expression profiles, more than 500 transcripts that were expressed at significantly different levels in normal and neoplastic cells were identified. These data provide insight into the extent of expression differences underlying malignancy and reveal genes that may prove useful as diagnostic or prognostic markers.