Ia Antigens as Restriction Molecules in Ir-Gene Controlled T-Cell Proliferation

作者：Zoltán Á. Nagy, Zenrō Ikezawa, Matko Marušić, Constantin N. Baxevanis, Norihisa Ishii, J Klein · 发表于：Humana Press eBooks · 年份：1983 · DOI：10.1007/978-1-4612-5633-5_59 · 被引用次数：125 · 研究领域：T-cell and B-cell Immunology、Monoclonal and Polyclonal Antibodies Research、Immune Cell Function and Interaction

Restriction molecules involved in proliferative T-cell response were determined by blocking of the responses with monoclonal antibodies specific for either A (A α A β ) or E (E α E β ) molecules. Non- Ir -gene controlled responses to a large number of antigens were found to be channelled through both A and E molecules. In contrast, responses under Ir -gene control were always restricted to one of the two class II molecules (either A or E), and the class II context of recognition of a given antigen remained the same in all (or almost all) responder haplotypes. This remarkable consistency in channelling of the response to a given antigen via either A or E molecules is termed selective restriction. Selective restriction seems to operate also in the generation of suppressor T cells: thus far, we have found three Ir -gene controlled responses, in which recognition of the antigen together with E (but not A) molecules leads to Ts-cell generation. These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.