Pten signaling in gliomas

作者：Christiane Brigitte Knobbe-Thomsen · 发表于：Neuro-Oncology · 年份：2002 · DOI：10.1215/15228517-4-3-196 · 被引用次数：145 · 研究领域：Electrochemical Analysis and Applications

In 1997, the PTEN gene (phosphatase and tensin homolog deleted on chromosome 10) was identi ed as a tumor suppressor gene on the long arm of chromosome 10.Since then, important progress has been made with respect to the understanding of the role of the Pten protein in the normal development of the brain as well as in the molecular pathogenesis of human gliomas.This review summarizes the current state of the art concerning the involvement of aberrant Pten function in the development of different biologic features of malignant gliomas, such as loss of cell-cycle control and uncontrolled cell proliferation, escape from apoptosis, brain invasion, and aberrant neoangiogenesis.Most of the tumor-suppressive properties of Pten are dependent on its lipid phosphatase activity, which inhibits the phosphatidylinositol-3 9 -kinase Pten signaling in gliomas 1,2