Differences of Clinical Features and Prognosis between Mycoplasma Pneumoniae Necrotizing Pneumonia and Non-Mycoplasma Pneumoniae Necrotizing Pneumonia in Children

作者：Beilei Yang, Weili Zhang, Wenjing Gu, Xinxing Zhang, Meijuan Wang, Li Huang, Canhong Zhu, Yongdong Yan, Wei Ji, Huiping Ni, Zhengrong Chen · 发表于：Research Square · 年份：2021 · DOI：10.21203/rs.3.rs-150833/v1 · 被引用次数：1 · 研究领域：Pneumonia and Respiratory Infections、Respiratory viral infections research、Microbial infections and disease research

Abstract Background In the past few years, Mycoplasma pneumoniae (MP) infection has been reported more in China . However, there are few studies on the clinical characteristics and prognosis of necrotizing pneumonia (NP) caused by different pathogens. Methods A retrospective analysis was performed, including 31 children with a clinical diagnosis of NP in the hospital from January 1, 2013 to January 31, 2020. A total of 11 children with MPNP were included in the observation group and the other 20 children with other pathogens were included in the control group. The clinical manifestations, laboratory data, imaging findings, treatments and outcomes were analyzed. Results The proportion of dyspnea cases was significantly higher in the non- Mycoplasma pneumoniae necrotizing pneumonia (N-MPNP) group than that in the Mycoplasma pneumoniae necrotizing pneumonia (MPNP) group ( P = 0.02).The LDH level of all patients in the MPNP group was higher than the normal value, with a median value of 805.0 U/L, which was significantly higher than those in the N-MPNP group (414.0 [299.9–540.6] U/L; Z = −2.518; P = 0.012). The white blood cells (WBCs) count of the N-MPNP group was 17.8 (11.1–21.7) × 10 9 /L, which was significantly higher than that of the MPNP group (10.2 [6.3–14.1] × 10 9 /L; P < 0.05). The mean time of pulmonary necrosis in the MPNP group was 20.9 ±6.9 days, which was higher than that of the N-MPNP group (16.8 ±6.1 days; t = 3.101; P = 0.004). The incidence of pleural effusi...