PRIMARY ALDOSTERONISM

作者：Bryan Hudson, A Barnett, Joel C. Bornstein · 发表于：Australasian Annals of Medicine · 年份：1957 · DOI：10.1111/imj.1957.6.3.250 · 被引用次数：10 · 研究领域：Hormonal Regulation and Hypertension、Adrenal Hormones and Disorders、Adrenal and Paraganglionic Tumors

SUMMARY A female patient, aged thirty‐one years, suffering from primary aldosteronism due to adrenal adenoma (Conn's syndrome) is described. She presented with hypertension of the order of 240/120 millimetres of mercury associated with weakness, polyuria up to five litres a day, and an electrocardiogram showin;STdepression and prominentUwaves in various leads. The serum potassium content was lowered, and there was marked alkalosis with a failure to concentrate urine. The urine contained aldosterone in concentration of 10 to 11 microgrammes per litre, and the plasma aldosterone level was approximately • 8 microgrammes per 100 millilitres. A left suprarenal tumour, demonstrated by presacral air insufflation, was removed at operation. The hypertension and metabolic abnormalities reverted to normal. The alkalosis appeared to be secondary to the hypokælemia and was partly corrected by administration of potassium citrate. Observations suggested that the defect in urine concentration was due to antagonism to antidiuretic hormone. Methods used for estimating mineralo‐corticoid activity of plasma and urine are outlined.