PHOSPHOINOSITIDE KINASES

作者：David A. Fruman, Rachel E. Meyers, Lewis C. Cantley · 发表于：Annual Review of Biochemistry · 年份：1998 · DOI：10.1146/annurev.biochem.67.1.481 · 被引用次数：1365 · 研究领域：Cellular transport and secretion、Protein Kinase Regulation and GTPase Signaling、Erythrocyte Function and Pathophysiology

Phosphatidylinositol, a component of eukaryotic cell membranes, is unique among phospholipids in that its head group can be phosphorylated at multiple free hydroxyls. Several phosphorylated derivatives of phosphatidylinositol, collectively termed phosphoinositides, have been identified in eukaryotic cells from yeast to mammals. Phosphoinositides are involved in the regulation of diverse cellular processes, including proliferation, survival, cytoskeletal organization, vesicle trafficking, glucose transport, and platelet function. The enzymes that phosphorylate phosphatidylinositol and its derivatives are termed phosphoinositide kinases. Recent advances have challenged previous hypotheses about the substrate selectivity of different phosphoinositide kinase families. Here we re-examine the pathways of phosphoinositide synthesis and the enzymes involved.