Carriage ofStreptococcus pneumoniae3 Years after Start of Vaccination Program, the Netherlands

作者：Judith Spijkerman, Elske J. M. van Gils, Reinier H. Veenhoven, Eelko Hak, F. Yzerman, Arie van der Ende, Alienke J. Wijmenga‐Monsuur, Germie P. J. M. van den Dobbelsteen, Elisabeth A. M. Sanders · 发表于：Emerging infectious diseases · 年份：2011 · DOI：10.3201/eid1704.101115 · 被引用次数：85 · 研究领域：Pneumonia and Respiratory Infections、Respiratory viral infections research、Bacterial Infections and Vaccines

To evaluate the effectiveness of the 7-valent pneumococcal conjugate vaccine (PCV7) program, we conducted a cross-sectional observational study on nasopharyngeal carriage of Streptococcus pneumoniae 3 years after implementation of the program in the Netherlands. We compared pneumococcal serotypes in 329 prebooster 11-month-old children, 330 fully vaccinated 24-month-old children, and 324 parents with age-matched pre-PCV7 (unvaccinated) controls (ages 12 and 24 months, n = 319 and n = 321, respectively) and 296 of their parents. PCV7 serotype prevalences before and after PCV7 implementation, respectively, were 38% and 8% among 11-month-old children, 36% and 4% among 24-month-old children, and 8% and 1% among parents. Non-PCV7 serotype prevalences were 29% and 39% among 11-month-old children, 30% and 45% among 24-month-old children, and 8% and 15% among parents, respectively; serotypes 11A and 19A were most frequently isolated. PCV7 serotypes were largely replaced by non-PCV7 serotypes. Disappearance of PCV7 serotypes in parents suggests strong transmission reduction through vaccination.