Antimicrobial activity of wax and hexane extracts from Citrus spp. peels

作者：Susana Johann, Vetúria Lopes de Oliveira, Moacir Geraldo Pizzolatti, Jan Schripsema, Raimundo Braz‐Filho, Alexsandro Branco, Artur Smânia · 发表于：Memórias do Instituto Oswaldo Cruz · 年份：2007 · DOI：10.1590/s0074-02762007000600004 · 被引用次数：47 · 研究领域：Essential Oils and Antimicrobial Activity、Plant chemical constituents analysis、Natural Products and Biological Research

Antibacterial and antifungal properties of wax and hexane extracts of Citrus spp. peels were tested using bioautographic and microdilution techniques against three plant pathogenic fungi (Penicillium digitatum, Curvularia sp., and Colletotrichum sp.), two human pathogens (Trichophyton mentagrophytes and Microsporum canis), and two opportunistic bacteria (Escherichia coli and Staphylococcus aureus). Two polymethoxylated flavonoids and a coumarin derivative, were isolated and identified from peel extracts, which presented antimicrobial activity especially against M. canis and T. mentagrophytes: 4',5,6,7,8-pentamethoxyflavone (tangeritin) and 3',4',5,6,7,8-hexamethoxyflavone (nobiletin) from C. reticulata; and 6,7-dimethoxycoumarin (also known as escoparone, scoparone or scoparin) from C. limon.