The FlyBase Database of the Drosophila Genome Projects and community literature

发表于：Nucleic Acids Research · 年份：1999 · DOI：10.1093/nar/27.1.85 · 被引用次数：326 · 研究领域：Insect-Plant Interactions and Control、Insect symbiosis and bacterial influences、Insect behavior and control techniques

The FlyBase Drosophila genetics database and the public interfaces of the Berkeley Drosophila Genome Project (BDGP) and European Drosophila Genome Project (EDGP) are in the process of integrating.At present, the data of these projects are available from independent, but hyperlinked, WWW sites (FlyBase URL, http://flybase.bio.indiana.edu/; BDGP URL, http://fruitfly.berkeley.edu/; EDGP URL, http://edgp.ebi.ac.uk/ ).Because of the considerable overlap of data classes between the contributions of the Drosophila genome projects and the Drosophila community, the new and enlarged FlyBase consortium views the implementation of a single integrated Drosophila genomics/genetics server as essential to the scientific community.This integration will occur in a stepwise fashion over the next 1-2 years.In this report, the salient features of the current databases and how to interrogate and navigate the extensive data sets are discussed. BACKGROUNDThe fruit fly, Drosophila melanogaster, is one of the most studied eukaryotic organisms and a central model for the human genome project.Introduced as an experimental organism in the early years of this century, the genetic prowess of D.melanogaster has placed this fly at the forefront of many areas of research, notably gene regulation, chromosome behavior, developmental biology, cell biology, neurobiology, population biology, ecology and evolution.Beginning in 1992, data on the genetics and genomics of D.melanogaster and related species have been e...