Graves' Ophthalmopathy

作者：Rebecca S. Bahn · 发表于：New England Journal of Medicine · 年份：2010 · DOI：10.1056/nejmra0905750 · 被引用次数：1568 · 研究领域：Ophthalmology and Eye Disorders、Blood disorders and treatments、Growth Hormone and Insulin-like Growth Factors

This article reviews the mechanisms that lead to the development of Graves' ophthalmopathy. A central feature in its development is autoimmunity that involves not only T cells, B cells, and macrophages but also fibroblasts and adipose tissue within the orbit. Intraorbital cytokine-mediated inflammation also has a prominent role. These recent findings suggest new ways of treating this debilitating disease.