Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation

作者：Yukihiko Kitamura, Seong-Ryeong Go, K. Hatanaka · 发表于：Blood · 年份：1978 · DOI：10.1182/blood.v52.2.447.447 · 被引用次数：651 · 研究领域：Mast cells and histamine、T-cell and B-cell Immunology、Immune Cell Function and Interaction

Abstract Production of tissue mast cells was evaluated in genetically anemic mice of W/Wv genotype and was found to be abnormal. In the skin of adult W/Wv mice the number of mast cells/cm was less than 1% of the number observed in the congeneic +/+ mice. No mast cells were detectable in other tissues of the W/Wv mice. After transplantation of bone marrow cells from +/+ mice the number of mast cells in the skin, stomach, caecum, and mesentery of the W/Wv mice increased to levels similar to those of the +/+ mice. These results show that the W/Wv mouse is a useful tool for the investigations concerning the physiologic roles and the origin of mast cells.