Acupuncture Treatments for Post-stroke Depression: A Systematic Review and Network Meta-analysis

作者：Lam Wai Ching, Hui Juan Li, Jianwen Guo, Liang Yao, Janita Pak Chun Chau, Suzanne Hoi Shan Lo, Chun Sum Yuen, Bacon Fung Leung Ng, Edwin Chau-Leung Yu, Zhaoxiang Bian, Alexander Yuk Lun Lau, Linda L. D. Zhong · 发表于：Research Square · 年份：2021 · DOI：10.21203/rs.3.rs-951353/v1 · 被引用次数：1 · 研究领域：Acupuncture Treatment Research Studies、Stroke Rehabilitation and Recovery、Botulinum Toxin and Related Neurological Disorders

Abstract Background: Depression is one of the most common complications after stroke, with a prevalence of 30-33%. Patients with post-stroke depression (PSD) usually experience anxiety, hopelessness, and insomnia, which have a negative impact on their daily activities and post-stroke rehabilitation. In this review, we aimed to explore the impact of acupuncture in alleviating symptoms of PSD and to evaluate the difference in effectiveness between acupuncture combined with pharmacotherapies and various non-pharmacotherapies in order to provide guides and advice for clinical personnel. Methods: Six databases (Cochrane Library, PubMed, EMBASE, China National Knowledge Infrastructure, Wanfang Database, Chongqing VIP Database) and two clinical trials registration platforms were searched from inception to May 2021. Randomized clinical trials (RCTs) comparing needle-based acupuncture with pharmacotherapy, and other non-pharmacotherapy or invalid group were included. Two independent reviewers identified eligible studies. Two reviewers independently abstracted and recorded data into a pre-made form. A Bayesian network meta-analysis (NMA) was conducted to assess and compare different techniques using RStudio 3.6.0. The primary outcome was the change in scores of scales measuring depressive symptoms. The secondary outcomes were changes in serotonin levels and in quality of life. Results: Fifty-nine RCTs were included. The results of this NMA showed that compared with western medicine (WM...