Dynamic measurement of the volumetric oxygen transfer coefficient in fermentation systems

作者：Biswadip Bandyopadhyay, Arthur E. Humphrey, Hiroyasu Taguchi · 发表于：Biotechnology and Bioengineering · 年份：1967 · DOI：10.1002/bit.260090408 · 被引用次数：338 · 研究领域：Fault Detection and Control Systems、Analytical Chemistry and Sensors、Water Quality Monitoring and Analysis

Abstract A rapid and internally consistent technique has been developed to measure the volumetric oxygen transfer coefficient, kLa, in fermentation systems. The method consists of tracing the dissolved O2 concentration of the fermentation broth during a short interruption of the aeration. The O2 concentration trace thus obtained can be analyzed to determine the values of kLa. Additional experiments on prolonged O2 starvation, carried out to find the limitation of the technique, suggest that O2 uptake rate will vary if a prolonged (2–10 min.) O2 starvation occurs.