Proviral integration site Mis-1 in rat thymomas corresponds to the pvt-1 translocation breakpoint in murine plasmacytomas.

作者：Luc Villeneuve, Éric Rassart, Paul Jolicoeur, Michael William Graham, Jerry M. Adams · 发表于：Molecular and Cellular Biology · 年份：1986 · DOI：10.1128/mcb.6.5.1834 · 被引用次数：49 · 研究领域：Ubiquitin and proteasome pathways、Glycosylation and Glycoproteins Research、Monoclonal and Polyclonal Antibodies Research

Two loci independently implicated in T-and B-lymphocyte neoplasia are shown to be equivalent. The Mis-1 locus is a common proviral integration site in retrovirally induced rat T lymphomas, while the pvt-1 locus on murine chromosome 15 frequently translocates to the kappa locus in plasmacytomas bearing 6;15 translocations. By comparing cloned sequences, we show that pvt-1 is the murine homolog of Mis-1.