Oxidase‐Like Activity of Polymer‐Coated Cerium Oxide Nanoparticles

作者：Atul Asati, Santimukul Santra, Charalambos Kaittanis, Sudip Nath, J. Manuel Perez · 发表于：Angewandte Chemie International Edition · 年份：2009 · DOI：10.1002/anie.200805279 · 被引用次数：1166 · 研究领域：Advanced Nanomaterials in Catalysis、Nanocluster Synthesis and Applications、Advanced biosensing and bioanalysis techniques

Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).