Pancreatic Adenocarcinoma

作者：David P. Ryan, Theodore S. Hong, Nabeel Bardeesy · 发表于：New England Journal of Medicine · 年份：2014 · DOI：10.1056/nejmra1404198 · 被引用次数：2369 · 研究领域：Pancreatic and Hepatic Oncology Research、Cancer Genomics and Diagnostics、Epigenetics and DNA Methylation

Cancer of the pancreas is predominantly adenocarcinoma and involves activating KRAS mutations in the large majority of cases. Surgical resection can be effective in localized disease; combination chemotherapy offers some palliation in advanced disease.