Text Messages to Improve Medication Adherence and Secondary Prevention After Acute Coronary Syndrome: The TEXTMEDS Randomized Clinical Trial

作者：Clara K Chow, Harry Klimis, Aravinda Thiagalingam, Julie Redfern, Graham S. Hillis, David Brieger, J. Atherton, Ravinay Bhindi, Derek P. Chew, Nicholas Collins, M. A. Fitzpatrick, C. Juergens, Nadarajah Kangaharan, Andrew Maiorana, Michele McGrady, Rohan Poulter, Pratap Shetty, J. Waites, Christian Hamilton‐Craig, Peter L. Thompson, Sandrine Stepien, Amy Von Huben, Anthony Rodgers, on behalf of the TEXTMEDS Investigators* · 发表于：Circulation · 年份：2022 · DOI：10.1161/circulationaha.121.056161 · 被引用次数：94 · 研究领域：Medication Adherence and Compliance、Mobile Health and mHealth Applications、Cardiac Health and Mental Health

Background: TEXTMEDS (Text Messages to Improve Medication Adherence and Secondary Prevention After Acute Coronary Syndrome) examined the effects of text message–delivered cardiac education and support on medication adherence after an acute coronary syndrome. Methods: TEXTMEDS was a single-blind, multicenter, randomized controlled trial of patients after acute coronary syndrome. The control group received usual care (secondary prevention as determined by the treating clinician); the intervention group also received multiple motivational and supportive weekly text messages on medications and healthy lifestyle with the opportunity for 2-way communication (text or telephone). The primary end point of self-reported medication adherence was the percentage of patients who were adherent, defined as >80% adherence to each of up to 5 indicated cardioprotective medications, at both 6 and 12 months. Results: A total of 1424 patients (mean age, 58 years [SD, 11]; 79% male) were randomized from 18 Australian public teaching hospitals. There was no significant difference in the primary end point of self-reported medication adherence between the intervention and control groups (relative risk, 0.93 [95% CI, 0.84–1.03]; P =0.15). There was no difference between intervention and control groups at 12 months in adherence to individual medications (aspirin, 96% vs 96%; β-blocker, 84% vs 84%; angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, 77% vs 80%; statin, 95% vs 95%; se...