Metabolic disorders on cognitive dysfunction after traumatic brain injury

作者：Jinqing Lai, Yan‐Chuan Shi, Shu Lin, Xiangrong Chen · 发表于：Trends in Endocrinology and Metabolism · 年份：2022 · DOI：10.1016/j.tem.2022.04.003 · 被引用次数：89 · 研究领域：Traumatic Brain Injury and Neurovascular Disturbances、Traumatic Brain Injury Research、Heme Oxygenase-1 and Carbon Monoxide

Cognitive dysfunction is a common adverse consequence of traumatic brain injury (TBI). After brain injury, the brain and other organs trigger a series of complex metabolic changes, including reduced glucose metabolism, enhanced lipid peroxidation, disordered neurotransmitter secretion, and imbalanced trace element synthesis. In recent years, several research and clinical studies have demonstrated that brain metabolism directly or indirectly affects cognitive dysfunction after TBI, but the mechanisms remain unclear. Drugs that improve the symptoms of cognitive dysfunction caused by TBI are under investigation and treatments that target metabolic processes are expected to improve cognitive function in the future. This review explores the impact of metabolic disorders on cognitive dysfunction after TBI and provides new strategies for the treatment of metabolic disorders.