WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour

作者：Shiu‐Ling Chen, Boting Liu, Wang-Pao Lee, Sin-Bo Liao, Yao-Bang Deng, Chia‐Lin Wu, Shuk-Man Ho, Bing-Xian Shen, Guan Hock Khoo, Wei-Chiang Shiu, Chih-Hsuan Chang, Hui‐Wen Shih, Jung‐Kun Wen, Tsuo‐Hung Lan, Chih‐Chien Lin, Yu-Chen Tsai, Huey‐Fen Tzeng, Tsai‐Feng Fu · 发表于：Nature Communications · 年份：2022 · DOI：10.1038/s41467-022-30165-2 · 被引用次数：10 · 研究领域：Neurobiology and Insect Physiology Research、Insect and Arachnid Ecology and Behavior、Plant and animal studies

Abstract The nervous and endocrine systems coordinate with each other to closely influence physiological and behavioural responses in animals. Here we show that WAKE (encoded by wide awake , also known as wake ) modulates membrane levels of GABA A receptor Resistance to Dieldrin (Rdl), in insulin-producing cells of adult male Drosophila melanogaster . This results in changes to secretion of insulin-like peptides which is associated with changes in juvenile hormone biosynthesis in the corpus allatum, which in turn leads to a decrease in 20-hydroxyecdysone levels. A reduction in ecdysone signalling changes neural architecture and lowers the perception of the male-specific sex pheromone 11-cis-vaccenyl acetate by odorant receptor 67d olfactory neurons. These finding explain why WAKE - deficient in Drosophila elicits significant male-male courtship behaviour.