Predictive value of serum YKL-40 and neutrophil/lymphocyte ratio for the severity of coronary artery disease in patients with acute ST-segment elevation myocardial infarction

作者：Caoyang Fang, Zhenfei Chen, Jianyuan Pan, Jing Zhang, Xiaoqin Jin, Mengsi Yang, Luyao Huang · 发表于：Research Square · 年份：2022 · DOI：10.21203/rs.3.rs-1600452/v1 · 被引用次数：2 · 研究领域：Public Health and Nutrition、Inflammatory Biomarkers in Disease Prognosis、Social and Behavioral Studies

Abstract Background: Acute ST-segment elevation myocardial infarction(STEMI) is a life-threatening coronary artery disease, inflammation plays a key role in the occurrence and development of coronary atherosclerosis. Serum YKL-40 and neutrophil-lymphocyte ratios(NLR) are both inflammatory markers. The purpose of this study is to investigate the predictive value of serum YKL-40 and neutrophil/lymphocyte ratio for the severity of coronary artery disease in patients with acute ST-segment elevation myocardial infarction. Methods : A total of 120 STEMI patients admitted from October 2020 to February 2022 were included in the STEMI group. 71 patients without coronary sclerosis who underwent coronary angiography at the same time were in the control group. They were divided into the high Gensini score group (Gensini score > 64 points) and the low Gensini score group (Gensini score ≤ 64 points). Pearson correlation analysis was used to analyze the correlation between serum YKL-40 and NLR and Gensini score in the STEMI group; Multifactorial logistic regression analysis was used to study the correlation of serum YKL-40 and NLR each with coronary artery lesion degree; Receiver operating characteristic curve (ROC) to evaluate the predictive value of serum YKL-40 and NLR on coronary artery lesion degree. Results : The serum YKL-40 and NLR in the STEMI group were higher than those in the control group, the serum YKL-40, and NLR in the high Gensini score group were higher than those in th...