Distribution and Drug Resistance of Bacterial Pathogens Associated with Lower Respiratory Tract Infection in Children and the Effect of COVID-19 on the Distribution of Pathogens

作者：Xuan Zhu, Ting Ye, Zhong Hong, Yaxuan Luo, Jian Xu, Qin Zhang, Xiaobo Luo, Qin Wang, Liyuan Zhang, Peipei Song, Jun Zhang · 发表于：Canadian Journal of Infectious Diseases and Medical Microbiology · 年份：2022 · DOI：10.1155/2022/1181283 · 被引用次数：25 · 研究领域：Pneumonia and Respiratory Infections、Respiratory viral infections research、Pediatric health and respiratory diseases

By studying the distribution and drug resistance of bacterial pathogens associated with lower respiratory tract infection (LRTI) in children in Chengdu and the effect of the COVID-19 on the distribution of pathogens and by analyzing the epidemic trend and drug resistance changes of the main pathogens of LRTI, this research is supposed to provide a useful basis for the prevention of LRTI in children and the rational use of drugs in clinical practice. Hospitalized children clinically diagnosed with LRTI in Chengdu Women and Children’s Central Hospital from 2011 to 2020 were selected as the study subjects. The pathogens of LRTI in children and the distribution of pathogens in different ages, genders, seasons, years, and departments and before and after the pandemic situation of COVID-19 were counted. The drug resistance distribution of the top six pathogens with the highest infection rate in the past three years and the trend of drug resistance in the past decade were analyzed. A total of 26,469 pathogens were isolated. Among them, 6240 strains (23.6%) were Gram-positive bacteria, 20152 strains (76.1%) were Gram-negative bacteria, and 73 strains (0.3%) were fungi. Klebsiella pneumoniae, Escherichia coli, Enterobacter cloacae, and Staphylococcus aureus were highly isolated in the group of infants aged 0-1 P < 0.01 , Moraxella catarrhalis and Streptococcus pneumoniae were highly isolated in children aged 1–6 P < 0.01 , and Haemophilus infl...