The Prognostic Significance of C-Reactive Protein to Albumin Ratio in Newly Diagnosed Acute Myeloid Leukaemia Patients

作者：Liurui Dou, Mingyue Shi, Juanjuan Song, Xiaona Niu, Junwei Niu, Shengjie Wei, Dan Li, Yanliang Bai, Kai Sun · 发表于：DOAJ (DOAJ: Directory of Open Access Journals) · 年份：2022 · 被引用次数：24 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Acute Myeloid Leukemia Research、Hematological disorders and diagnostics

Liurui Dou, Mingyue Shi, Juanjuan Song, Xiaona Niu, Junwei Niu, Shengjie Wei, Dan Li, Yanliang Bai, Kai Sun Department of Hematology, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, Henan, People’s Republic of ChinaCorrespondence: Kai Sun; Yanliang BaiDepartment of Hematology, Zhengzhou University People’s Hospital and Henan Provincial People’s Hospital, No. 7 Weiwu Road, Jinshui District Zhengzhou, Henan, 450003, People’s Republic of China, Tel +86-18237110038; +86-13783605211, Email sunkai@cellscience.org; yanliangbai@126.comBackground: The ratio of C-reactive protein to albumin (CAR) is an inflammatory marker that has been demonstrated to be a simple and reliable prognostic factor in several solid tumours and chronic lymphocytic leukaemia (CLL). However, no studies have investigated the prognostic value of the CAR in patients with acute myeloid leukaemia (AML).Objectives and Methods: We retrospectively analysed 212 newly diagnosed non-M3 AML patients. Using the receiver operating characteristic curve (ROC) method, the optimal cut-off value for CAR was determined. We investigated the correlations of the pretreatment CAR levels with clinical characteristics, treatment response of induction chemotherapy, overall survival (OS) and event-free survival (EFS). We also assessed the prognostic value of the CAR compared with other inflammation-based prognostic parameters by the area under the curve (AUC).Results: According to the ROC curve,...