Fluorescent Imaging-Guided Chemo- and Photodynamic Therapy of Hepatocellular Carcinoma with HCPT@NMOFs-RGD Nanocomposites
作者：Yue Shang, Hui Zhang, Yajia Cheng, Peipei Cao, Jianlin Cui, Xue‐Bo Yin, Saijun Fan, Yuhao Li · 发表于：Dove Medical Press (Taylor and Francis Group) · 年份：2022 · 被引用次数：14 · 研究领域：Nanoplatforms for cancer theranostics、Photodynamic Therapy Research Studies、Nanoparticle-Based Drug Delivery
Yue Shang,1,* Hui Zhang,2,* Yajia Cheng,3 Peipei Cao,3 Jianlin Cui,3 Xuebo Yin,4 Saijun Fan,1 Yuhao Li5 1Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, Peopleâs Republic of China; 2Shanghai Institute of Quality Inspection and Technical Research, Shanghai, Peopleâs Republic of China; 3Department of Pathology, Nankai University School of Medicine, Tianjin, Peopleâs Republic of China; 4College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, Peopleâs Republic of China; 5Beijing Geriatric Medical Research Center, Xuanwu Hospital, Capital Medical University, Beijing, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Yuhao Li, Xuanwu Hospital, Capital Medical University, Beijing, 100053, Peopleâs Republic of China, Tel +86-10-83198269, Email liyuhao@xwh.ccmu.edu.cnBackground: Hepatocellular carcinoma (HCC), arising from hepatocytes, is the most common primary liver cancer. It is urgent to develop novel therapeutic approaches to improve the grim prognosis of advanced HCC. 10-hydroxycamptothecin (HCPT) has good antitumor activity in cells; however, its hydrophobicity limits its application in the chemotherapy of HCC. Recently, nanoscale porphyrin metal-organic frameworks have been used as drug carriers due to their low biotoxicity and photodynamic properties.Methods: Nanoscale zirconium porp...